A new study led by Massachusetts General Hospital investigators finds that heart failure patients who underwent bariatric surgery to treat morbid obesity had a significant reduction in the incidence of heart failure exacerbation - a dangerous, sudden worsening of symptoms - in the two years following surgery.

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Novartis today announced that the United States Food and Drug Administration approved Afinitor (everolimus) tablets for the treatment of adult patients with progressive, well-differentiated, nonfunctional neuroendocrine tumors (NET) of gastrointestinal (GI) or lung origin that are unresectable, locally advanced or metastatic.

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Work out with Tracy Anderson and meet other Health experts at our wellness weekend at Canyon Ranch in Lenox, Mass., April 22-24, 2016! You'll get to participate in exclusive fitness and cooking classes, and listen to inspiring speakers. For more visit http://ift.tt/1AYb7dA #HealthTotalWellness

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Omega-3 fatty acids may lower the risk of breast cancer in postmenopausal obese women, according to researchers.

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For patients with obesity trying to lose weight, the greatest health benefits come from losing just 5 percent of their body weight, according to a new study at Washington University School of Medicine in St. Louis.

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Five squat variations so you can chisel your core and build a better butt

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The intestinal microbiota is necessary to ensure optimum postnatal growth and contributes to determining the size of adult individuals, notably in the event of undernutrition.

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BistroMD, the leader in home diet meal delivery, announced a licensing partnership today with Fitness Icon Denise Austin to create a branded meal-delivery program. The program is a natural extension of bistroMD's mission to empower people to lose weight while eating great tasting, nutritious foods, and blends with Denise's healthy lifestyle philosophy.

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You'd like to do something—anything—to speed up your metabolism, but it's out of your control. Right? Not quite. Although genetics and your age both play a role, recent studies suggest you have plenty of say over how well your metabolism—which involves your body's ability to break down food into usable energy—functions.

In fact, you can all but negate the metabolic slowdown that happens after 40 by tweaking your diet, exercise, and sleep habits. "Think of your body as an engine—your metabolism is the rate at which your engine runs," explains Scott Isaacs, MD, an endocrinologist in Atlanta and author of Hormonal Balance: How to Lose Weight By Understanding Your Hormones and Metabolism. "By making adjustments to these three elements, you can actually make your engine rev higher."

The eating and exercise plans on these pages were designed to keep your metabolism humming to the tune of up to 10 pounds off in 21 days. Read on for the keys to not only losing, but losing for good.

Key 1: Eat early
Your basal metabolic rate—the number of calories your body burns at rest—is based on things like age, height, and body type, so there isn't much you can do to alter it. But there is a lot you can do to change the number of calories you burn above that, beginning with your diet. Specifically: Eat breakfast.

We already know the reasons you may not want to (you don't have the time/energy/stomach for it), but leaving for work on an empty stomach is like hitting the pause button on your metabolism. Here's why: When your brain senses your stomach is empty, it sends a message to your cells to conserve energy in case another meal doesn't arrive. In other words, your body holds onto the fat stored in your cells instead of helping you burn it off.

"Breakfast triggers a process called thermogenesis, where the body signals the brain to activate the metabolic process of turning food into energy," says Mark Hyman, MD, author of The Blood Sugar Solution.

Key 2: Eat often
To keep your metabolism humming, Dr. Hyman suggests eating small meals every three or four hours. Aim to make each of those meals at least one-quarter protein—whether it's animal protein, beans, or dairy, says Marissa Lippert, RD, who designed the eating plan on page 39. A recent study in the journal Neuron suggests that consuming protein stimulates the cells responsible for switching on the body's calorie-burning mechanism.

Foods high in sugar and processed carbs, on the other hand, can lead to another problem: insulin resistance. "As we get older, it's crucial to pay attention to how much sugar we're consuming," says Diane Kress, RD, author of The Metabolism Miracle. "Too much messes with your metabolism by causing your body to store extra calories as fat."

Key 3: Sweat off the weight
Even more important? Exercise. "Not only does it affect your metabolism while you're doing it, but research shows you can keep burning calories up to 24 hours after you finish because your metabolism stays elevated," Dr. Isaacs says.

That's especially true if you challenge yourself: A new study in the journal Cell Metabolism suggests that intense bouts of exercise can "turn on" genes responsible for energy metabolism. Researchers found that the activation of these fat- burning genes was higher in cyclists who pedaled at 80 percent of their aerobic capacity versus those who did a more moderate cycling session at 40 percent. So although you can't permanently change your DNA (if only!), experts say exercise can fire up certain genes that initiate the fat-burning process.

Exercise is particularly helpful once you pass the age of 40, when your metabolism naturally begins to slow down. Experts used to believe it slowed due to an inevitable loss of muscle mass. However, a study in the journal The Physician and Sports Medicine found that fit women ages 41 to 81 who continued to exercise four to five times a week as they got older had little change in body composition. The real reason you lose muscle with age? You stop using it. "We now know that women who keep up a regular vigorous fitness routine don't experience the metabolic decrease," Dr. Isaacs says.

Key 4: Sleep away the pounds
No, it's not your imagination. Too little sleep can cause you to gain—and not just because you're spending those extra waking hours in front of the TV nursing a bag of chips. Research suggests that people who sleep two-thirds of their usual amount (five hours instead of eight, say) eat an average of 549 extra calories the following day without realizing it. Experts believe this is because too few zzz's upset the balance of important appetite-regulating hormones.

But that's not all: A Swedish study found that even one night of disrupted sleep can cause the body to burn up to 20 percent fewer calories the following day. "Sleep deprivation impacts multiple hormones related to metabolism," Dr. Isaacs says. "Resistance to leptin—a hormone that regulates body weight—increases, while levels of ghrelin, a hormone that signals to your brain that you're hungry, also increase."

Aim for seven to eight hours of pillow time a night, advises Dr. Hyman. "Just a small change in your sleep schedule can make a big difference in your health." Not to mention your ability to burn calories.



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Obesity is not only a risk factor for developing knee arthritis. It is also linked to less favorable outcomes after joint replacement surgery. A study at Hospital for Special Surgery (HSS) in New York City finds that bariatric surgery prior to total knee replacement (TKR) is a cost-effective option to improve outcomes.

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A new randomized controlled study conducted by Indiana University School of Medicine researchers and published online today in the American Journal of Public Health found that adults with prediabetes who followed a nationally-available weight management program with a prediabetes-specific component, Weight Watchers, lost significantly more weight and experienced better blood glucose control than those following a self-initiated program using supplemental counseling materials.

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There's a reason so many of us struggle with losing weight (and keeping it off). Cutting-edge research is pointing toward a surprising new explanation—one that has little to do with lack of willpower. (Thank goodness.) In fact, the problem is that you've been doing what you were told to do—slash calories, cut fat.

Conventional wisdom holds that weight loss is nothing more than simple math. Take in fewer calories than you expend, and the pounds will fall off as predictably as leaves from an autumn tree. But thousands of failed diets have shown that the low-calorie approach doesn't work, says David Ludwig, MD, an endocrinologist at Boston Children's Hospital and a professor at Harvard Medical School. "When you cut calories, the body fights back, making you hungrier, among other things," he explains. "Weight is controlled by our biology more than our willpower."

RELATED: 16 Ways to Lose Weight Fast

What's more, despite everything you've heard for years, all calories aren't created equal. "Although a bottle of cola and a handful of nuts may have the same number of calories, they have dramatically different effects on metabolism," says Dr. Ludwig. (Bet you can guess which is worse.)

Three new books offer insights into the latest thinking on smart eating, and they're all penned by eminent weight-loss experts: Dr. Ludwig; Louis Aronne, MD, director of the Comprehensive Weight Control Center at Weill Cornell Medicine and NewYork-Presbyterian Hospital; and Mark Hyman, MD, director of The Cleveland Clinic Center for Functional Medicine. Health chatted with these groundbreaking diet crusaders to uncover what we all need to know to slim down and stay healthy for good.

Minimize simple carbs
"The 'calorie is a calorie' myth is perhaps the most misleading nutrition lie ever," says Dr. Hyman. Here's why: Sugary snacks and drinks and low-fat, highly processed starches raise blood sugar quickly, which triggers your pancreas to release a flood of insulin—the hormone Dr. Ludwig calls "the ultimate fat cell fertilizer" because it instructs your body to store calories as fat, causing fat cells to increase in number and size.

Once insulin ushers calories into your fat cells, it closes the door, restricting their ability to get out. With calories, aka fuel, trapped in your fat cells, there's too little glucose and too few lipids circulating in the bloodstream to power your brain and muscles. Your brain, sensing the fuel shortage, prompts you to feel hungry and slows down your metabolism—the worst possible combination for long-term weight control.

RELATED: 26 Weight-Loss Myths You Shouldn't Believe

"Overeating hasn't made our fat cells grow," says Dr. Ludwig, whose book is titled Always Hungry?. "Processed carbs and added sugar have programmed our fat cells to grow, and that makes us overeat." And it becomes a vicious cycle. Break it: "If you're going to have simple carbs, like bread with dinner, have them after you've eaten some protein and veggies first," says Dr. Aronne. "Our studies show that when you save them for later in the meal, they don't trigger as big a bump in blood sugar—or insulin."

Enlist your metabolism
Doctors have long known that when you lose weight, your metabolism slows down, says Dr. Aronne, author of The Change Your Biology Diet. "If you lose 10 percent of your body weight, the number of calories you burn during the day drops by 30 to 40 percent, because a smaller body requires fewer calories and your muscles become more efficient," he says. But research shows that what you eat when you're trying to shed pounds can determine how big a hit your metabolism takes.

In a 2012 study published in JAMA, Dr. Ludwig and his colleagues looked at 21 people between the ages of 18 and 40 who were overweight or obese. They had each participant lose about 10 to 15 percent of their body weight, then put them on three different maintenance diets—low-fat (with about 60 percent of daily calories coming from carbs); low-glycemic-index (with about 40 percent of daily intake from carbs that cause only moderate spikes in blood sugar, such as legumes and vegetables); and a very low-carb approach, with just 10 percent of daily calories from carbs. All three diets involved the same total number of calories. And every participant tried each diet for a month.

RELATED: The Best Weight Loss Foods of All Time

After each diet period, the researchers tested the folks' metabolic rates—and found that the low-carb diet completely prevented the metabolic slowdown often seen after weight loss. "People on the low-carb diet burned an average of 325 more calories a day—about the same number you'd burn during a moderately vigorous workout—than those on the low-fat diet, and those on the low-glycemic diet burned 150 more calories than those on the low-fat diet," he says. One theory for why that happens: Reducing processed carbs, and as a result insulin levels, allows fat cells to release calories back into the bloodstream, helping to readjust the body-weight set point naturally, speculates Dr. Ludwig. He posits that reducing carbs even moderately—with a focus on the quality of your carbs—would be beneficial for shedding weight as well.

Let go of your fear of fat
"Dietary fat has been unfairly demonized," says Dr. Aronne. "Olive oil, nuts and monounsaturated fats play an important role in a healthy diet, and these days the jury is even out on saturated fat." Dr. Ludwig agrees: "The fats in dairy appear to be healthier than those in red meat, and saturated fat is worse when you eat it in combination with processed carbs." Fat can actually be surprisingly helpful when you're trying to lose weight. Healthy fats can shut off craving centers in the brain and help you eat less sugar and refined carbs—"the primary cause of obesity and diabetes," says Dr. Hyman, whose book is titled Eat Fat, Get Thin.

One of the strongest studies vindicating fat was published in The New England Journal of Medicine several years ago. In it, researchers assigned 322 overweight people to either a low-fat diet, a moderate-fat Mediterranean diet or a low-carb, high-fat, high-protein diet. The trial lasted two years—a relative lifetime in the realm of diet studies. What they discovered: Those on the low-carb, high-fat diet not only lost the most weight but also had the most favorable changes in heart-disease-related factors, like levels of triglycerides and HDL cholesterol.

Don't cut too many calories
Sure, if you starve yourself, you'll slim down, so it seems like the strategy would be an instant success. But eventually everyone regains. Why? "Because when you drastically reduce the amount you eat, your body launches potent countermeasures designed to prevent additional weight loss," says Dr. Ludwig—and the more weight you lose, the more fiercely the body tries to gain it back.

RELATED: 57 Science-Backed Weight Loss Tips

For one thing, it shifts into conservation mode and simply burns fewer calories, notes Dr. Aronne. In addition, he says, levels of hunger- and satiety-related hormones change to increase your desire to eat, making you feel less satisfied with a reasonable amount of food and more obsessed with high-calorie, highly processed goodies. "It's sort of like your brain goes haywire," explains Dr. Aronne, "and you can no longer trust the messages it's sending about hunger and fullness."

But eating the right foods can help you minimize these biological defenses. The key: Consume a satisfying amount of protein, high-quality fat and fiber-rich, low-starch carbs from veggies, legumes, nuts, and seeds. "When you eat that kind of diet, insulin levels decrease and you reprogram your fat cells to release excess calories," says Dr. Ludwig. "So there's more glucose and lipids available as fuel—which means you're not battling hunger and your metabolism stays high."

To bolster these new dietary strategies, there's some tried-and-true advice you should absolutely abide by: Move more, sleep plenty, stress less—all of which can keep insulin levels, as well as hunger and satiety hormones, at optimal levels, says Dr. Ludwig. Diet guidance may evolve, but these three fundamentals have stood the test of time.

RELATED: 31 Quick-and-Easy Fat-Burning Recipes

A day of eating, reimagined
While each MD's diet approach varies in its specifics, the general strategy is the same: To keep your body from fighting your slimdown efforts, eat whole foods with adequate protein and plenty of healthy fat, and reduce sugar, refined carbs and processed foods. Here are a few recipes pulled from the pages of their books.

Morning
Breakfast: Southwest omelet made from 4 to 6 egg whites with onions, peppers, tomatoes and salsa, plus 2 slices of turkey bacon.

A.M. snack: 1 small container of plain Greek yogurt with ½ cup of blueberries.

From Dr. Aronne's The Change Your Biology Diet ($26, amazon.com)

Midday
Lunch: California kale Cobb salad with ½ bunch kale, ¼ avocado, 3 or 4 halved cherry tomatoes, ¼ can water-packed artichoke heart quarters, 1 slice of turkey bacon and 4 ounces of diced, cooked chicken.

Snack: ¼ cup of raw, organic nuts and seeds. For a greater nutritional punch, soak them in warm salt water overnight, rinse thoroughly, then dry in the oven at no more than 120 degrees.

From Dr. Hyman's Eat Fat, Get Thin ($28, amazon.com)

Evening
Dinner: 1/3 pound of white-fleshed fish or salmon broiled with garlic and lemon, plus ½ medium roasted sweet potato and 1 cup of chopped greens (such as chard or kale) sautéed in olive oil, garlic and a pinch of salt.

Dessert: ½ medium pear, apple, peach or apricot poached with cinnamon, cardamom and ground nutmeg.

From Dr. Ludwig's Always Hungry? ($28, amazon.com)



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Small proteins that affect communication between cells play an important role in regulating inflammation that occurs during inflammatory bowel disease, according to researchers at Georgia State University, Emory University, the University of Michigan and Amgen, a biotechnology company.

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Helsinn, the Swiss pharmaceutical Group focused on building quality cancer care, today announce that they have entered into distribution, license and supply agreements with Mundipharma and its network of independent associated companies granting exclusive rights to anamorelin in Norway, Finland, Sweden, Denmark and Iceland.

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Eating breakfast causes obese people to be more active, according to the latest research published from researchers at the University of Bath (UK).

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The Telecommunications Engineer Nora Millor-Muruzábal has designed a new measuring tool that provides objective, quantifiable data to improve the diagnosis of frailty syndrome, a set of symptoms that render elderly people more vulnerable.

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It's no secret that heart disease is the leading cause of death for adult men and women in this country. It kills one of every four people. While many of us associate February with red-ruffled hearts and chocolate candy for Valentine's Day, it's also "American Heart Month" to raise awareness of the importance of making healthy lifestyle choices to improve overall heart health.

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You know that one friend that never worries about weight and seems to stay effortlessly slim? That friend, and others like them might unknowingly possess secrets to helping those who struggle with their weight.

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Give every meal an upgrade with these hot superfood add-ins—all it takes is a sprinkle or scoop.

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Our favourite foods could be made healthier thanks to a new technique developed by the University of Leicester which has identified harmful bacterial molecules in certain processed foods such as burgers and ready meals.

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Yes, stomach pudge may be stubborn, but here are a slew of research-proven ways to dump it for good.

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From hiking boots to lightweight clothing, all the gear you need to enjoy the great outdoors all summer long.

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A new study published in the Journal of the American Heart Association found that a diet containing unsaturated fats, such as those found in walnuts and olive oil, has similar weight loss effects as a lower fat, higher-carbohydrate diet.

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Health's fitness editor picks the road and trail sneakers that will rock your world.

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Did you know your neck crick or shoulder ache may actually mean you're tight somewhere else? Troubleshoot your sore spots and work out the real pain points in just a few minutes a day.

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According to a new literature review in the February issue of the Journal of the American Academy of Orthopaedic Surgeons, a team-based care approach (consisting of the patient, family members, the orthopaedic surgeon and other medical practitioners) on total knee replacement (TKR) procedures, in conjunction with newer pain management strategies, is key to maximizing patient outcomes.

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This exercise requires that you get into a modified plank pose, alternating tapping your feet out on each side. Watch this video for a demonstration on how to do a full-body cardio move. You will feel the burn in your arms, shoulders, core, and legs.

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This modified push-up exercise will give you killer arms in no time. Watch this video to see how you can sculpt stronger arms using your own body weight.

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There is no equipment required for this effective exercise, and you'll see great results in your legs. Watch this video for a demonstration on how to do a leg-sculpting move to give you leaner, tighter legs.

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This move gets your heart pumping by keeping you active and engaging your core. Watch this video to see how to do an easy but effective cardio move that you can do in your living room.

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This quick exercise targets your abs and your obliques to give you a toned and flat stomach. In this video, watch a FlyBarre instructor demonstrate how to work your abs by doing a plank and side crunch combination move.

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Over the past few years, body mass index, a ratio of a person's height and weight, has effectively become a proxy for whether a person is considered healthy. Many U.S. companies use their employees' BMIs as a factor in determining workers' health care costs. And people with higher BMIs could soon have to pay higher health insurance premiums, if a rule proposed in April by the Equal Employment Opportunity Commission is adopted.

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This is a great move to throw into your strength training routine if you want to add some cardio into the mix. It involves no equipment so you can do it anywhere. Watch this video for a demonstration on how to do heel clicks.

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These small pulses might not feel like much, but they make a huge difference in toning the muscles throughout your legs, especially your hips. Watch this video to see a FlyBarre instructor demonstrate how to do a leg pulse exercise for lean stems.

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Use a small stability ball behind your lower back to engage your core in this ab strengthening move. Watch this video to see a FlyBarre instructor demonstrate how to do this move so you can get a flat belly and tight abs in no time.

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The outer hip is a difficult area to reach, but strengthening it is important to keep you limber and injury-free. Watch this video to see how to strengthen and tone your outer hip so you can stay healthy with a slim physique.

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Score killer abs and a strong core with this simple workout from the founder of AKT InMotion. Watch this video to see how to get into a modified side plank in order to build strength and tone your abs.

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Increasing weight loss from middle age through the later stages of life may be an indicator of mild cognitive impairment, suggest study findings.

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University of Massachusetts Medical School researchers have found a way to more efficiently delivery a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I that may also prove to be safer for use in humans.

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